A stainless steel laminar flow hood is an essential piece of equipment in various industries, including pharmaceuticals, biotechnology, electronics, and healthcare. These hoods provide a controlled environment that ensures the cleanliness and sterility of critical processes. When selecting the size and configuration of a stainless steel laminar flow hood for a specific application, several key considerations must be taken into account to ensure optimal performance, efficiency, and safety. In this comprehensive guide, provided by Cleatech LLC, we will explore the factors that should influence your decision-making process, helping you make an informed choice that meets the unique needs of your application.

Understand Your Application

Before diving into the technical details of selecting a laminar flow hood, it’s crucial to have a clear understanding of your specific application. Different applications have varying requirements for cleanliness, airflow, and workspace, and these factors will heavily influence your choice of hood size and configuration. Start by asking the following questions:

What type of work will be conducted within the laminar flow hood? (e.g., microbiological research, electronics assembly, pharmaceutical compounding)

What are the cleanliness and sterility requirements of your application?

How many operators will be working in the hood simultaneously?

What are the size and dimensions of the equipment or materials that will be placed inside the hood?

Determine the Required Cleanliness Level

One of the primary functions of a laminar flow hood is to provide a clean and sterile environment for sensitive processes. The cleanliness level required for your application will dictate the type of laminar flow hood you need. There are two main categories of laminar flow hoods:

  1. Class II Biological Safety Cabinets (BSCs): These cabinets are suitable for applications that require the highest level of protection against biological contaminants. They provide containment and protection for both the operator and the environment. Class II BSCs come in three classes: A1, A2, and B2, each with specific airflow patterns and containment capabilities.
  2. Clean Benches: Clean benches are ideal for applications that require a clean and sterile working environment but do not involve hazardous materials. They provide a laminar flow of HEPA-filtered air over the workspace, ensuring the sterility of the work area.

Understanding the cleanliness level required for your application is essential in selecting the appropriate laminar flow hood.

Calculate Workspace Size

The size of the workspace inside the laminar flow hood is a critical factor to consider. It should accommodate your equipment, materials, and operators comfortably while ensuring proper laminar airflow distribution. To determine the required workspace size, consider the following:

Measure the dimensions of the equipment or materials that will be placed inside the hood.

Calculate the necessary working space around the equipment or materials to ensure ease of operation.

Determine the number of operators who will work simultaneously inside the hood and allocate sufficient space for them.

Ensure that the hood’s interior dimensions meet your specific application’s requirements.

A cramped workspace can hinder efficiency and compromise the laminar airflow, leading to inadequate protection for your processes.

Assess Airflow Velocity and Uniformity

Laminar flow hoods rely on a uniform and controlled airflow to maintain cleanliness and sterility. Airflow velocity is a critical parameter that directly impacts the performance of the hood. The required airflow velocity depends on the cleanliness level needed for your application:

ISO Class 5 (Class 100): Typically requires an average airflow velocity of 0.45 m/s (90 ft/min).

ISO Class 6 (Class 1000): Requires an average airflow velocity of 0.33 m/s (65 ft/min).

It’s important to note that these values are guidelines, and specific applications may have different requirements. Ensure that the laminar flow hood you choose can provide the necessary airflow velocity and uniformity to meet your cleanliness goals.

Choose Between Horizontal and Vertical Airflow

Laminar flow hoods come in two main airflow configurations: horizontal and vertical. Each configuration has its advantages and is better suited for specific applications:

a. Horizontal Laminar Flow Hoods:

Airflow travels horizontally across the workspace.

Ideal for applications where the operator needs to work with materials that emit particulate contaminants.

Commonly used in electronics assembly and pharmaceutical compounding.

b. Vertical Laminar Flow Hoods:

Airflow travels vertically from the top of the hood down to the workspace.

Suitable for applications requiring a high level of cleanliness and sterility.

Often used in microbiological research, cell culture, and tissue culture work.

Your choice between horizontal and vertical airflow should align with the specific requirements of your application.

Consider Ergonomics and Operator Comfort

The comfort and safety of operators working within the laminar flow hood are paramount. Consider the following ergonomic factors when selecting the hood size and configuration:

Ensure that the hood’s height is adjustable to accommodate operators of different heights comfortably.

Evaluate the lighting within the hood to provide adequate illumination for tasks.

Check the availability of ergonomic features such as sloped sashes, armrests, and footrests.

Opt for a hood design that minimizes operator fatigue during extended work periods.

Operator comfort and safety are essential for maintaining productivity and ensuring the success of your application.

Evaluate Filtration System and Efficiency

The filtration system of a laminar flow hood plays a vital role in maintaining cleanliness and sterility. High-efficiency particulate air (HEPA) filters are commonly used to remove airborne contaminants. Consider the following factors related to the filtration system:

Check the type and efficiency of the HEPA filters used. HEPA filters should meet or exceed the required cleanliness standards for your application.

Assess the accessibility and ease of replacing filters when they reach the end of their lifespan.

Ensure that the hood has a filter monitoring system to alert operators when filter replacement is needed.

Regular filter maintenance is essential to maintain the performance and effectiveness of the laminar flow hood.

Plan for Environmental Factors

Environmental factors can influence the performance of a laminar flow hood. Consider the following environmental factors when selecting the hood size and configuration:

Room Temperature and Humidity: Ensure that the room where the laminar flow hood will be installed maintains a stable temperature and humidity level within the recommended range for your application.

Room Airflow: Prevent turbulence in the room by controlling the airflow patterns and minimizing drafts that can disrupt the laminar airflow within the hood.

Room Contamination Sources: Identify potential sources of contamination within the room, such as open windows, doors, or high-traffic areas, and take measures to mitigate them.

Addressing these environmental factors is crucial for the effective operation of the laminar flow hood.

Consider Future Expansion and Upgrades

When investing in a laminar flow hood, it’s important to think about future needs and the potential for expansion or upgrades. Consider the following:

Evaluate whether the selected hood can accommodate future changes in your processes or additional equipment.

Check if the hood can be upgraded with advanced features or technology to meet evolving requirements.

Assess the availability of spare parts and support for maintenance and repairs.

Planning for the long-term usability of your laminar flow hood can save you time and resources in the future.

Budget and Cost of Ownership

The cost of a laminar flow hood extends beyond the initial purchase price. Consider the total cost of ownership, which includes ongoing operational costs, maintenance, and energy consumption. Factors to consider include:

Energy Efficiency: Choose a hood with energy-efficient components and airflow settings to reduce operating costs.

Maintenance Requirements: Evaluate the maintenance needs, including filter replacement, and budget for ongoing upkeep.

Warranty and Support: Ensure that the manufacturer offers a comprehensive warranty and reliable customer support.

Balancing your budget constraints with the requirements of your application is essential when selecting a laminar flow hood.


Selecting the right size and configuration of a stainless steel laminar flow hood for a specific application is a critical decision that can impact the success of your processes and the safety of your operators. By thoroughly understanding your application’s requirements, assessing cleanliness levels, calculating workspace size, and considering factors like airflow, ergonomics, filtration, and environmental conditions, you can make an informed choice that ensures optimal performance and efficiency.

Cleatech LLC offers a range of stainless steel laminar flow hoods designed to meet various industry needs. When working with Cleatech, you can expect expert guidance, quality products, and ongoing support to ensure the success of your cleanroom or laboratory operations. By carefully considering the factors outlined in this guide, you can confidently choose the right laminar flow hood that aligns with your specific application and performance requirements.

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